Glucosamine HCL

Glucosamine HCL is a natural compound that is found in healthy cartilage. Glucosamine is a normal constituent of glycoaminoglycans in cartilage matrix and synovial fluid. It has been shown through many studies to alleviate pain and help rebuild cartilage. Glucosamine is commonly used in patients with osteoarthritis, and may allow for reduced doses of non-steroidal anti-inflammatory agents. It is primarily derived from shellfish and has the possibility to create an allergic reaction in people that are sensitive to shellfish.

MSM

MSM, methylsulfonylmethane (METH-?l-sul-FON-il-METH-ane) provides sulfur, a vital building block of joints, cartilage, skin, hair and nails, and methyl groups, which support many vital biochemical processes in the body, including energy production. MSM is a naturally occurring nutrient found in small amounts of many foods. As a dietary supplement, MSM is synthesized. When made correctly, it is identical to that found in nature. MSM can be taken alone or in combination with other joint health supplements, such as glucosamine and Cetyl Myristoleate.

Hyaluronic Acid (HA)

Hyaluronic acid (also called hyaluronan or HA) is the primary component of the Synovial fluid found in the joints. As we age, hyaluronic acid level drops, which can cause our joints to become weak. Synovial fluid that protects joints is largely made up of hyaluronic acid and acts as a lubricant, shock absorber and nutrient carrier. HA has been shown to be effective in the treatment of different types of arthritis such as osteoarthritis and rheumatoid arthritis. Glucosamine sulfate is often combined with hyaluronic acid to create a complete joint support formula.

Yucca

Yucca is a medicinal plant native to Mexico. According to folk medicine, yucca extracts have anti-arthritic and anti-inflammatory effects. The plant contains several physiologically active phytochemicals. It is a rich source of steroidal saponins, and is used commercially as a saponin source. Saponins have diverse biological effects, including anti-protozoal activity. It has been postulated that saponins may have anti-arthritic properties by suppressing intestinal protozoa which may have a role in joint inflammation. Yucca is also a rich source of polyphenolics, including resveratrol and a number of other stilbenes (yuccaols A, B, C, D and E). These phenolics have anti-inflammatory activity. They are inhibitors of the nuclear transcription factor NFkappaB. NFkB stimulates synthesis of inducible nitric oxide synthase (iNOS), which causes formation of the inflammatory agent nitric oxide. Yucca phenolics are also anti-oxidants and free-radical scavengers, which may aid in suppressing reactive oxygen species that stimulate inflammatory responses.